In-Vitro Ophthalmological Testing
Products that may come into contact with the eyes require ophthalmologist-testing strategies to confirm that formulations do not irritate the eyes. Products such as creams, serums and cosmetics applied to the face, as well as shampoos and conditioners, require these testing strategies.
Formulation evaluation is necessary when introducing novel ingredients, ingredient vehicles, processing methods, or ingredient combinations and/or when making a specific safety claim (e.g., “Safe for Sensitive Eyes,” “Ophthalmologist Tested,” “Safe for Contact Lens Wearers,” etc.). Ingredients should be evaluated for safety in the final product concentration ranges, both individually and in when combined in the final product, to assess for the possibility of adverse interactions.
Tiered approaches to ophthalmologist testing examine all available data to produce a well-rounded safety evaluation. Typically, tiered approaches require a toxicological profile and clinical assessments.
CPT has state-of-the-art analytical, microbiological, clinical, photobiology, and in-vitro toxicology testing laboratories, all of which are at your disposal in the determining of product safety, efficacy and efficiency.
Using our specialized departments and well-respected lab facility, we test a wide range of products at CPT. Our in-house experts offer guidance to determine the efficacy of your products while ensuring compliance and accommodating your budgetary concerns.
CPT can execute tiered approaches that include both toxicological profiling, as well as clinical assessments to help our clients substantiate ophthalmological claims. Severe eye irritants are evaluated by our team using several regulatory agency-accepted in vitro and ex vivo ophthalmological tests, including but not limited to:
- Bovine Corneal Opacity and Permeability (BCOP) Assay
- Hen’s Egg Test on the Chorioallantoic Membrane (HET-CAM) Assay
It is also recommended that formulations in clinical studies are tested to support confidence in formulation safety for human use.
Based on the individual needs of our clients, we offer a wide range of support across various departments. Since initial product testing can be fairly complex in terms of a high-quality, safe and trusted product, our clients typically explore the benefits of numerous departments and areas of expertise, including:
- Clinical —Efficacy trials can be performed for safety, consumer in-use, and to support claims, such as ‘dermatologist-tested’ and ‘ophthalmologist-tested.’
- In-Vitro Safety — Our in-vitro safety department assists clients when they are looking to perform non-animal or animal-free toxicology testing.
- Microbiology — Microbial contamination and preservative testing is key to cosmetic products.
- Photobiology —From SPF and Water Resistant claims to PhotoAllergy and Phototoxicity studies, CPT is the world leader in sunscreen testing.
- Analytical — From raw materials, batch release, and stability shelf-life testing to “free-of” and low-level detection claims, our analytical department ensures that all requirements are met based on industry standards.