The EpiOcular EIT is an in vitro assessment assay that has the ability to differentiate articles that are ocular irritants from articles that are not ocular irritants. The EIT is accepted as OECD TG 492.
The Bovine Corneal Opacity and Permeability test method (BCOP) is an in vitro test method that can be used to classify substances as ‘ocular corrosives and severe irritants’. The BCOP is accepted as OECD TG 437.
The EpiOcular MTT ET-50 (Neat) method is a risk assessment assay based on the effective time at which a material (applied neat) causes a 50% reduction in tissue viability (ET-50). Based on the ET-50, the test article is categorized into one of 4 classifications ranging from non-irritating to severe/extreme which correspond to groupings of Rabbit Draize Eye Scores (MMAS).
The EpiOcular MTT ET-50 (Dilution) method is similar to the MTT ET-50 Neat method. This assay is based on the effective time at which a material (diluted to 20% in water) causes a 50% reduction in tissue viability (ET-50). Based on the ET-50, the test article is categorized into one of 4 classifications ranging from non-irritating to severe/extreme which correspond to groupings of Rabbit Draize Eye Scores (MMAS). This method is recommended for surfactant based solutions and is applicable to water-soluble materials with a specific gravity of > 0.95.
The EpiOcular Sub Draize Ultra-Mildness Test. This assay is routinely utilized for mild materials for which the Draize test is insensitive. This highly reproducible assay allows for quantifiable discrimination among mild, milder and mildest product formulations.
The HET-CAM (Hen’s Egg Test Chorio-Allantoic-Membran) assay was developed for irritation studies as an alternative method to replace the Draize ocular irritation test. It can be used to determine quickly, reliably and inexpensively, the ocular irritation potential of virtually all product types.f