In-Vitro Ophthalmological Testing

Products that may come into contact with the eyes require ophthalmologist-testing strategies to confirm that formulations do not irritate the eyes. Products such as creams, serums and cosmetics applied to the face, as well as shampoos and conditioners, require these in vitro testing strategies.

Formulation evaluation is necessary when introducing novel ingredients, ingredient vehicles, processing methods, or ingredient combinations and/or when making a specific safety claim (e.g., “Safe for Sensitive Eyes,” “Ophthalmologist Tested,” “Safe for Contact Lens Wearers,” etc.). Ingredients should be evaluated for safety in the final product concentration ranges, both individually and in when combined in the final product, to assess for the possibility of adverse interactions.

Tiered approaches to ophthalmologist testing examine all available data to produce a well-rounded safety evaluation. Typically, tiered approaches require a toxicological profile and clinical assessments.

Our In-Vitro Testing Capabilities

CPT has state-of-the-art analytical, microbiological, clinical, photobiology, and in-vitro toxicology testing laboratories, all of which are at your disposal in the determining of product safety, efficacy and efficiency.

Using our specialized departments and well-respected lab facility, we test a wide range of products at CPT. Our in-house experts offer guidance to determine the efficacy of your products while ensuring compliance and accommodating your budgetary concerns.

CPT can execute tiered approaches that include both toxicological profiling, as well as clinical assessments to help our clients substantiate ophthalmological claims. Severe eye irritants are evaluated by our team using several regulatory agency-accepted in vitro and ex vivo ophthalmological tests, including but not limited to:

Hen’s Egg Test on the Chorioallantoic Membrane (HET-CAM) Assay
EpiOcular EIT
EpiOcular MTT ET-50 (Neat or dilution)
EpiOcular Sub Draize Ultra-Mildness Test

It is also recommended that formulations in clinical studies are tested to support confidence in formulation safety for human use.

Our Departments

Based on the individual needs of our clients, we offer a wide range of support across various departments. Since initial product testing can be fairly complex in terms of a high-quality, safe and trusted product, our clients typically explore the benefits of numerous departments and areas of expertise, including:

Clinical — Efficacy trials can be performed for safety, consumer in-use, and to support claims such as ‘dermatologist-tested’ and ‘ophthalmologist-tested.’
In-Vitro Toxicology — Our In-Vitro Toxicology department assists clients when they are looking to perform non-animal (animal-free) toxicology testing.
Microbiology — Microbial contamination and preservative efficacy testing are key to cosmetic and OTC drug products.
Photobiology — From SPF and Water-Resistant claims to Photoallergy and Phototoxicity studies, CPT℠ is the world leader in sunscreen testing.
Analytical — From raw materials, product batch release, and stability shelf-life testing to “free-of” and low-level detection claims, our analytical department ensures that all requirements are met based on industry standards.
Consulting – Our consulting staff can perform GMP and GLP audits of your facilities or vendors, help create SOPs, develop testing programs, etc.

Analytical

Clinical

Photobiology

Microbiology

In-Vitro Toxicology

Consulting

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In-Vitro Ophthalmological Testing